CytoCell P299

Oil Free Anti-Wrinkle Serum
2 points per dollar


This concentrated treatment serum utilizes P299™, a scientifically advanced stem technology Polypeptide, helps strengthen skin by activating the natural renewal process. Additional anti-aging ingredients—including Hyaluronic Acid and Marine Algae Extracts—not only even out the appearance, but also restore essential hydration. The result is a healthy-looking, radiant complexion that is unbelievably smooth.

  • P299™ is a scientifically proven active ingredient that helps stimulate the production of healthy skin.
  • A blend of three Advanced Peptides diminishes the look of fine lines and wrinkles.
  • Marine Algae Extract and Hyaluronic Acid Complex provide immediate and long-term moisturization and help restore the skin’s natural capacity to retain moisture.


How to Use

AM and PM. Use twice a day. Apply 2 pumps to clean, dry face and neck. Allow serum to absorb into skin and follow with a moisturizer.


Water/Aqua/Eau, Plumeria Acutifolia Flower Extract, Glycerin, Propanediol, Sodium Oleate, Hydrogenated Lecithin, sh-Polypeptide-5, Disodium EDTA, Glycine Soja (Soybean) Extract, Polyacrylate-13, Polyisobutene, Hyaluronic Acid, Hydrolyzed Chondrus Crispus Extract, Hydroxypropyl Cyclodextrin, Sodium Hyaluronate, Palmitoyl Tripeptide-38, Algae Extract, Carrageenan, Polysorbate 20, Hydrolyzed Soy Protein, Soy Amino Acids, Yeast Extract/Faex/Extrait de levure, Glutamine, Glutamic Acid, Dextran, Caprooyl Tetrapeptide-3, Citric Acid, Ethylhexylglycerin, Phenoxyethanol
    • I really love this serum. It makes my skin feel smooth and soft and it looks great!

      (Posted on 6/10/14) Review by Cheryl
    • Loved the way this made my skin feel...not oily...just soft and iit absorbes so well!

      (Posted on 6/9/14) Review by Cindy
    • I received this product as a sample size and I love it! It absorbs quick and feels super light on my skin and doesn't make it oily. As someone who doesn't use a serum, I am definitely going to purchase this moving forward.

      (Posted on 6/8/14) Review by Lindsay
    • Love the way it feels but as of yet, I have not noticed any amazing results. I'm hoping that with continued use, that will change..

      (Posted on 3/6/14) Review by Sharon
    • After using a sample of the cytocell cream, I'm a bit disappointed in this serum. I read all kinds of glowing reviews but it isn't making me glow. Maybe I should give it more time. I'm still trying to figure out which products give me the best results. I'm not sorry that I have this- but probably won't purchase it again. I expected much more from this product, considering the list of ingredients.

      (Posted on 3/4/14) Review by Lee-Anne
    • lovely light texture, white lotion look to it, a bit more powerful as a serum than the oil free serum. it makes a great base for makeup or to other moisturizers. no scent and sinks in, I love this!

      (Posted on 2/20/14) Review by silvia
    • anti-aging serum that doesn't make my face break out. It sinks right into the skin, isn't shiny or greasy...just makes my skin look like it has a nice glow. Also seems to be diminishing the fine lines on my forehead and around the mouth area.

      (Posted on 1/30/14) Review by Beth
    • This product has a very nice feel and plumping effect to the skin upon application. It wears well under makeup and layers with ease under and or over other product. I really like the way my skin feels after use and my skins overall clarity, brightness is improved but I am not sure if this is a heavy hitting anti aging serum as of yet. So far it is looking promising

      (Posted on 1/24/14) Review by Cynthia
    • No joke. This serum makes me feel beautiful. The way it plumps up my skin is amazing and I adore both the way my skin looks and feels in the morning after sleeping with it on. Highly recommend.

      (Posted on 1/14/14) Review by allison
    • I wanted to love this but I haven't noticed a big difference in my skin. I use in the morning and at night. My skin feels great after using but I honestly have not noticed a difference in how it looks.

      (Posted on 1/9/14) Review by Tara
    • I was a bit disappointed in this product after reading all the reviews. It's okay, but not great on my skin.

      (Posted on 1/8/14) Review by Lynne
    • Love this serum even better than my Caudalie serum. It makes me skin feel plump, glowy and calm. Works great under moisturizers, but I mostly use it at night alone (with a good hydrating eye cream).

      (Posted on 1/7/14) Review by Maggie
    • This serum is the perfect texture and smell, and that's just a few of the reasons why it's my favorite serum! I've been using it for a while now, and like it much better than any of the other Kate serums. It soaks in nicely leaving your skin feeling soft and moisturized. It's great layered under the CytoCell moisturizer too!

      (Posted on 1/2/14) Review by Jennifer
    • I use this at night, as my skin tends to get oily throughout the day. It makes my face feel smooth and slightly diminishes fine lines. It works good as a night time moisturizer.

      (Posted on 12/18/13) Review by Michelle
    • First thing I thought was "the product looks heavy" because it's an anti-aging product. However, it was super light and works wonders. Also, if you still think it's too heavy, you can use it as a moisturizer and just apply sunscreen after. Your skin looks less saggy after a while (almost done with the bottle)

      (Posted on 12/5/13) Review by David
    • I received a sample of this serum and just loved how it made my skin feel so soft. I don't know what it does, but my blemished have reduced and my skin is now more clear. Wish it wasn't so expensive as I need two pumps of this to cover my face well, unlike Quench (use in the am) that only takes a half a pump.

      (Posted on 11/30/13) Review by Xuan
    • I use this after DermaQuench and before Age Arrest ... my skin feels GREAT - better than ever before. I love Kate's products and feel like I am using the best possible products for my skin and getting a head start at age 39 !!

      (Posted on 11/8/13) Review by Paula
    • AN AWESOME serum.

      (Posted on 9/28/13) Review by JENNY
    • i tried samples of this along with some other high end skin care brands. have used estee lauder, bobbi brown, clinique skin care and wasted that money literally coz none of the products suited me. all were oily and led to acne on my face. but this product is a completelydifferent story. its so non-oily, smooth and hydrating and made my skin glow. i just love it.

      (Posted on 9/6/13) Review by anshu jain
    • I love this product! not only have I seen a great difference of the texture and wrinkles, but it has also helped considerably with my acne which is an added bonus!

      (Posted on 8/26/13) Review by Ashley
    • This serum is light and hydrates my skin without breaking me out or feeling heavy. I wear it under Age Arrest and Daily Deflector Waterlight sunscreen and there is no pilling/balling up of products as it sinks in quickly. No break outs either!

      (Posted on 8/1/13) Review by Mandy
    • Botox in a bottle!

      (Posted on 7/23/13) Review by Jody
    • This serum is by far the best one I have ever used. I bought a bottle of it and only use it on the areas that i need it, which would be my laugh lines and forehead. This product was recommended to me as "botox in a bottle" and I have had SO many compliments on my skin. I have been asked if I've had botox. I am only 25 so i dont have deep wrinkles, but i have noticable fine lines from smiling and being in the sun. The results I have got are amazing and I have had friends and family buy it after seeing my results. I would recommend this product even if you just have fine lines. Mine are barley noticeable and i am so happy about that! I hope you love it just as much!

      (Posted on 4/22/13) Review by Lindie
    • I use this Serum twice a day after I wash and tone before I apply my moisturizer. I have seen a dramatic difference in my skin since I started using Kate Somerville products. I love this product because it is light weight and effective! I have seen a reduction in fine lines in my forehead. This is a must have product for me!

      (Posted on 3/16/13) Review by Jen
    • I am so grateful to have found an anti-aging product that works well for sensitive, oily and acne prone skin. It has helped even out my skin tone, while helping prevent acne. I also noticed, while using this, my skin was more balanced and not as oily. A+ in my book. I plan on making it a key component in my skin care regiment throughout the summer months!!

      (Posted on 2/5/13) Review by Rebekah
    • My Kate specialist recommended this product, though I wanted to try another serum, and I'm glad I took her advice! This product smooths my skin and works against wrinkles. It is a must have in my skincare regimen!

      (Posted on 1/29/13) Review by Christy
    • I've been using this product for a week (2x a day) in conjunction with the deep tissue cell repair cream at night and an oil-free moisturizer during the day. Over the last week I've noticed a reduction in fine lines around my mouth and eyes, a decrease in pore size, and my complexion has evened out. I attribute most of this to the P299 product, but can't ignore that the reduction in fine lines could be due to the deep tissue cell repair cream. I know it's not the oil-free moisturizer bevmcause I've been using it for over a year, though I think it pairs nicely with this product to keep my oil production down and keep a matte finish for daytime.

      My only gripe is the size. 1oz doesn't seem like it would last very long, which could make it a pricey addition to my beauty regimen. But I'm not sure I want to go back to my old skin... So it's worth it.

      (Posted on 9/9/12) Review by Lea

Clincal Results


  • In just 2 weeks, 77% of women showed improved skin elasticity and firmness.
  • In just 4 weeks, 91% of women showed a significant increase in moisture.
  • In just 4 weeks, 77% of women said their skin’s overall appearance was improved and healthier-looking.

* Results based on an independent Clinical Study.